| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| TB 2339100 | Macra LP(a) | 12x8 tests | 15-20 days | x |
Macra LP(a)The Macra Lp(a) Enzyme Linked Immunosorbant Assay (ELISA) kit, is an in vitro diagnostic device for the quantitative measurement of Lp(a), in human serum or plasma, for the assessment of risk for coronary heart disease (CHD) in specific populations, along with other risk factors. Lipoprotein (a) [Lp(a)] is a spherical lipid particle found predominantly in the 1.006 to 1.021 g/mL density range. Similar to low-density lipoprotein (LDL) in core lipid composition and having B-100 as a surface apolipoprotein (apo B), Lp(a) differs from LDL by containing an additional glycoprotein, apolipoprotein(a) [apo(a)]. The apo(a) portion of Lp(a) is heterogeneous 12 resulting from a variation in the number of protein domains known as kringles. One of these domains is known to repeat 12 to 52 times forming as many as 40 different isoform sizes and weights. Numerous studies beginning in the 1970s have reported an association of Lp(a) with coronary heart disease (CHD). Since then, a considerable amount of literature has been generated further documenting an association of elevated Lp(a) levels with increased risk of coronary artery disease (CAD), and premature CAD in Caucasian males. Both familial studies and studies in different ethnic populations have shown that Lp(a) levels are generically determined. Families with a history of CAD frequently have higher than expected levels of Lp(a). The Lp(a) levels in different ethnic populations can vary widely. Africans or peoples of African decent generally have Lp(a) levels higher than Caucasians and Asians while Native Americans generally have levels lower than Caucasians. This variability of Lp(a) levels by ethnic population requires careful interpretation of results based on a knowledge of the patient and other cardiac risk factors which may be present. Appendix I provides more detailed information about the association of lipoprotein(a) levels with coronary artery disease and the expected levels in different populations. |
Additional Documentation
|
Login