PAI, t-PA & uPA

Order number	Description	Quantity	Delivery time	CE
TC 11110	TC scu-PA ELISA Reagent Set	5 plates	7 days

TC scu-PA ELISA Reagent Set

The scu-PA Elisa can be used to detect elevated scu-PA antigen levels which may be associated with certain disease states such as tumours of the gastrointestinal or urogenital tracts.

Human urokinase (u-PA) is an enzyme which functions as an activator of the fibrinolytic enzyme system. Its ability to lyse fibrin clots makes it useful as an effective thrombolytic agent in the management of a variety of clinical disease states including pulmonary embolism and localized thrombosis. Urokinase is synthesized by and released from numerous cell types
including endothelial cells, kidney cells and macrophages. Several malignant tumors, especially those of the urogenital and gastrointestinal tracts, have been shown to produce increased quantities of urokinase. Urokinase exists in three major forms: enzymatically inactive single chain urokinase or pro- urokinase (scu-PA), enzymatically active two chain urokinase (tcu-PA) and urokinase-inhibitor complexes. scu-PA circulates in plasma at a concentration of 1-2ng/mL and is converted to tcu-PA in vivo by the action of plasmin and kallikrein Each form of u-PA displays a different activity, different affinities for Glu-plasminogen, and different rates
of inhibition by plasma protease inhibitors. For therapeutic administration, pro-urokinase is generally preferred over other forms of this plasminogen activator. Pro-urokinase is not inhibited by plasminogen activator inhibitors and, although no form of urokinase is highly fibrin specific, prourokinase is more fibrin-oriented than other forms of u-PA. During thrombolytic therapy, pro-urokinase is converted to the active two chain urokinaseand is then susceptible to inhibition.

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Kordia Life Sciences

PAI, t-PA & uPA

TC scu-PA ELISA Reagent Set