| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| TC 12080 | TC t-PA/PAI-1 Complex ELISA Kit | 1 plate | 7 days |
TC t-PA/PAI-1 Complex ELISA KitThe t-PA-PAI-1 complex ELISA is useful for the detection of elevated amounts of t-PA-PAI-1 complex in patients with liver disease: Plasminogen Activator Inhibitor Type I (PAI-1) is the major inhibitor of tissuetype plasminogen activator (t-PA). In the resting state, the body’s plasma concentration of PAI-1 greatly exceeds the t-PA plasma level and even following physical exertion or venous occlusion, conditions which lead to increased t-PA levels, PAI-1 is usually available in adequate amounts to compensate for increased activator levels. Thus, increases in t-PA-PAI-1 complexes as long as active, non-complexed PAI-1 is available. Certain pathological conditions are associated with increased t-PA values. The liver is the major site of t-PA degradation and hepatic disorders are often accompanied by increased t-PA levels and, thus, increased t-PA-PAI-1 complex values. In healthy persons, the t-PA level increases with age and complex levels rise accordingly. The quantitation of t-PA-PAI-1 complexes aids in the interpretation of alterations in the levels of t-PA and/or PAI-1. Since the liver, in addition to being a site of t-PA degradation, is an organ of PAI-1 synthesis the quantitation of activator-inhibitor complexes may serve as and indicator of the extent to which active PAI-1 is available to compensate for a reduction in the hepatic degradation of t-PA, i.e. elevation of t-PA plasma values. The detection of elevated t-PA-PAI-1 complex values may be useful for the diagnosis of liver dysfunctions which may result in clotting disorders. |
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