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Plasmin, Plasminogen & Alpha2-antiplasmin

Order number Description Quantity Delivery time CE
TC 11040 Glu Plasminogen EIA Set 5 plates 7 days

Glu Plasminogen EIA Set

The Glu-plasminogen ELISA is useful for the determination of Gluplasminogen levels, particularly in patients with thromboembolic complications, those undergoing lytic therapy or in cases of hyperfibrinolysis.

Plasminogen is the inactive precursor of plasmin, the central enzyme responsible for fibrinolysis. Plasminogen, which is synthesised by the liver, is a 92,000 dalton single-chain glycoprotein. It circulates in plasma in a concentration range between 60-250 μg/mL with a half life of 2.2 days. Through the action of certain proteases such as tissue-type plasminogen
activator or urokinase, a single peptide bond in the plasminogen molecule is cleaved to yield the two chain molecule, plasmin. Plasmin's major function is physiologic clot dissolution through the degradation of the insoluble polymer fibrin into soluble fragments. Thus, the concentration of plasminogen is one of the numerous factors critically influencing the rate of
fibrinolysis in vivo.

Plasminogen levels are often depressed in both acute and chronic hepatic
disease. This may be due either to decreased synthesis or increased consumption
during disseminated intravascular coagulation. In primary biliary
cirrhosis or early common bile duct obstruction plasminogen values are
normal or even elevated. Abnormally low plasminogen values have been
found in patients with generalized hyperfibrinolysis and neonates with
Lipström syndrome.



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