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Plasmin, Plasminogen & Alpha2-antiplasmin

Order number Description Quantity Delivery time CE
TC 11060 P-AP Complex EIA Set 5 plates 7 days

P-AP Complex EIA Set

The PAP complex test can be used to detect baseline as well as elevated levels of this complex which may occur during thrombotic events, in cases of endogenous hyperfibrinolysis and during thrombolytic therapy.

The physiologically most important plasmin inhibitor is the serpin a-2-antiplasmin It is a single chain 70 KD glycoprotein synthesized in the liver with a half-life of 3.3 days. The rapid reaction between plasmin and a-2-antiplasmin results in the formation of an inactive complex composed of one molecule of each component. Two steps are involved in this process. First a reversible complex is formed between the lysine binding sites on plasmin and complementary sites on the COOH-terminal region of the a-2-antiplasmin molecule. In a second step, an
irreversible complex is formed in association with the cleavage of a peptide bond
in the inhibitor. The plasma concentration of a-2-antiplasmin is approximately 1 μM or 70 μg/mL. Approximately 20% of a-2-antiplasmin present in plasma is crosslinked when blood is clotted. During thrombolytic therapy a-2-antiplasmin is consumed.


Measurement of plasmin-a-2-antiplasmin complexes (PAP complexes)
provides information concerning the extent of plasminemia and, thus, the
possibility of hemorrhagic phenomena. For this application the high level version
of the kit should be used. In all diseases which are accompanied by
increased fibrin formation and, thus, by an increased reactive plasminemia, one
encounters increased PAP complex formation and, in certain situations, there
exists a correlation between the occurrence of fibrin split pro-ducts and the
occurrence of PAP complexes. Thus, the determination of these complexes
serves as a good indicator of ongoing thrombotic-thrombolytic events. For this
application the low level version of the kit should be used.



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