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Plasmin, Plasminogen & Alpha2-antiplasmin

Order number Description Quantity Delivery time CE
TC 12040 Glu-Plasminogen ELISA kit 1 plate 7 days

Glu-Plasminogen ELISA kit

The Glu-plasminogen ELISA is useful for the determination of Gluplasminogen levels, particularly in patients with thromboembolic complications, those undergoing lytic therapy or in cases of hyperfibrinolysis.

Plasminogen is the inactive precursor of plasmin, the central enzyme responsible for fibrinolysis. Plasminogen, which is synthesized by the liver, is a 92,000 dalton single-chain glycoprotein. It circulates in plasma at a concentration of approximately 200 μg per mL with a half life of 2.2 days.
Through the action of certain proteases such as tissue-type plasminogen activator or urokinase, a single peptide bond in the plasminogen molecule is cleaved to yield the two chain molecule, plasmin. Plasmin's major function is physiologic clot dissolution through the degradation of the insoluble polymer fibrin into soluble fragments. Thus, the concentration of
plasminogen is one of the numerous factors critically influencing the rate of fibrinolysis in vivo.
Plasminogen levels are often depressed in both acute and chronic hepatic disease. This may be due either to decreased synthesis or increased consumption during disseminated intravascular coagulation. In primary biliary cirrhosis or early common bile duct obstruction plasminogen values are normal or even elevated. Abnormally low plasminogen values have
been found in patients with generalized hyperfibrinolysis and neonates with Lipström syndrome.



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