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Coagulation proteins

Order number Description Quantity Delivery time CE
HK 1300 Single Chain High Molecular Weight Kininogen (Fitzgerald Factor) 1 mg 7-10 days

Single Chain High Molecular Weight Kininogen (Fitzgerald Factor)

High Molecular Weight Kininogen (HK) is a non-enzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links Prekallikrein to a negatively charged surface thereby allowing activation of Kallikrein by surface bound Factor a-XIIa. HK also forms a complex with Factor XI and accelerates its activation to XIa by a-XIIa. Additionally HK serves as a source of Bradykinin, a potent vasoactive peptide important in hypotension studies. The protein purity is determined by SDS-PAGE.
Buffer Composition = 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3
Extinction Coefficient (1 %) = 7.01
Molecular weight = 120,000 daltons




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