| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| TB T3101 | TriniLIA D-Dimer | kit | 15-20 days | x |
TriniLIA D-DimerTriniLIA D-Dimer kit is a polystyrene, microparticle, agglutination assay for the quantitative determination of fibrin degradation products containing D-Dimer in citrated human plasma using automated coagulation analyzers.
Activation of the haemostatic system produces stabilized or cross-linked fibrin as its endproduct. The hydrolysis of fibrinogen molecules to form fibrin opens sites which allow the formation of affinity driven ternary complexes of fibrin, tissue plasminogen activator, and plasminogen, resulting in the formation of plasmin. Plasmin will cleave the crosslinked fibrin to form fibrin degradation products (FDP). Among these degradation products are species which contain Factor XIII mediated transglutaminase (lysine-glutamine) linkages between the carboxy terminal regions of adjacent fibrin(ogen) gamma chains. The globular domains containing these gamma chains are referred to as D-domains and fibrin degradation products containing adjacent D-domains crosslinked by Factor XIII are called D-Dimers. Antibodies have been developed which recognize epitopes for D-Dimer. Higher than normal levels of D-Dimer in plasma would appear to indicate the activation of coagulation with the formation of crosslinked fibrin and the subsequent proteolysis to release D-Dimer containing breakdown products. Elevated levels have been observed in disseminated intravascular coagulation (DIC), deep venous thrombosis (DVT), pulmonary embolism (PE)5 and in other disease states such as cancer. D-Dimer levels may rise in a normal pregnancy, but higher levels may indicate complications. Therefore, the presence of elevated< D-Dimer levels is not sufficient for the diagnosis of a thrombotic disorder. However, the absence of elevated D-Dimer levels may be used to help rule out the presence of a thrombotic< disorder, such as DIC, DVT or PE. In the TriniLIA D-Dimer assay, the polystyrene micro particles have monoclonal antibody< attached covalently. In the presence of multimeric D-Dimer antigen a complex forms. The formation of the complex causes an increase in the absorbance of the reaction mixture that is correlated to the antigen level. The TriniLIA D-Dimer procedure provides a means to quantitatively measure plasma levels of D-Dimer. The D-Dimer level may be used to determine patient management strategies. D-Dimer level can be expressed in D-Dimer or FEU. The concentrations provided in this document are expressed in D-Dimer units otherwise stated. For conversion table refer to "RESULTS" section. |
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