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ELISA sets & kits

Order number Description Quantity Delivery time CE
TC 11030 Fibronectin EIA Set 5 plates 7 days

Fibronectin EIA Set

The TC Fibronectin Test is used to measure human plasma fibronectin levels, particularly in patients with severe trauma, shock, sepsis, hepatic disease or clotting disorders.

Plasma fibronectin is a high molecular weight glycoprotein composed of two nearly identical polypeptide chains (each 220 kD). It is synthesised and secreted by the liver and circulates at a concentration of approximately 330μg/mL.
Fibronectin belongs to the group of "Cell Attachment Proteins". Its dimeric
structure allows it to function as a molecular glue, holding various molecules together through its binding domains. Principal binding domains exist for fibrin, heparin, Staphylococcus ureus, collagen and the cell surface. Fibronectin has been shown to play a role in fibrin clot formation, platelet function, fibrinolysis, chemotaxis, phagocytosis and opsonisation.
Lowered plasma fibronectin levels are associated with septicemia, trauma and are also observed during the post-operative period.
Hepatic disorders are also often associated with reduced fibronectin levels. Fibronectin binds to fibrin through factor XIII and levels may be reduced by activation of the clotting system.
Fibronectin is an "Acute Phase Protein" and its level may be elevated
during the acute phase. Certain malignancies are associated with high
fibronectin levels and this protein may play a role in cell metastasis.



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