| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| PF 800236 | Pefakit in-TDT | 2x40 tests | 10-15 days |
Pefakit in-TDTThe Pefakit® in-TDT® (TDT, Thrombin Dynamics Test; in, intrinsic pathway) allows a kinetic determination of initial thrombin formation in platelet-poor plasma by activation of the intrinsic coagulation pathway. Thrombin is the key enzyme of hemostasis: it cleaves fibrinogen, is the most potent physiological platelet activator, activates factor XIII and causes several positive and negative feedback reactions. Changes in the concentration of coagulation factors, activators or inhibitors quantitatively determine the kinetics of thrombin generation. Routine methods for the functional assessment of the plasmatic coagulation factors, such as aPTT or prothrombin time (PT), detect the time point of free thrombin formation but do not quantify its kinetics. The latter are thought to be of fundamental importance for the hemostatic process in vivo. A stimulus leading to weak thrombin formation in vitro may not result in any free thrombin formation in vivo where flow and cellular interaction are present. Quantifying thrombin formation may also provide clinically relevant data for the management of patients with diseaserelated hypercoagulation or thrombophilia. |
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