| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| PB FDPK-10 | Prekallikrein Depleted Plasma | 10x1 ml | 7-10 days | x |
Prekallikrein Depleted PlasmaCRYOcheck Prekallikrein Deficient Plasma is recommended for use as a deficient substrate in clot-based prekallikrein assays using the activated partial thromboplastin time (APTT). Deficiencies in coagulation factors may have congenital or acquired etiologies and can compromise in vivo hemostasis. Prekallikrein (Fletcher factor) is a single-chained glycoprotein with a molecular weight of 85,000-88,000 Da and is necessary for intrinsic coagulation. Plasma samples deficient in prekallikrein exhibit a prolonged APTT which shortens to normal on prolonged incubation with an activating reagent. Prekallikrein deficiency is commonly diagnosed through the use of a modified APTT assay. When a patient sample is mixed with prekallikrein deficient plasma, the degree of correction of the APTT is proportional to the level of prekallikrein in the patient plasma. |
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