| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| SABFV-AP | Sheep anti-bovine FV, Aff. Pur. | 0.5 mg | 7-10 days |
Sheep anti-bovine FV, Aff. Pur.Factor V (formerly referred to as accelerator globulin and labile factor) is a large single chain glycoprotein (330 kDa) that is produced in the liver. The concentration of FV in bovine plasma is approximately 35 µg/ml. FV is a procofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface. Other physiologic activators of FV include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (FVa) is an essential component of the prothrombin activator complex, which consists of FVa, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more FV to FVa. Thrombin also acts to down-regulate FVa indirectly by activating Protein C, which inactivates FVa cofactor activity. |
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