Facteur XIII & Factor XIII subunit A

Order number	Description	Quantity	Delivery time	CE
SAF13A-APBIO	Sheep anti-human FXIII subunit A, Aff. Pur. Biotiyilated	0.1 mg	7-10 days

Sheep anti-human FXIII subunit A, Aff. Pur. Biotiyilated

Factor XIII (FXIII, fibrin stabilizing factor) is the proenzyme form of a transamidase that is essential for normal haemostasis and fibrinolysis, wound healing, female fertility and foetal development. Extracellular FXIII consists of A subunits (83 kDa each) which contain the enzyme moiety, and B subunits (76 kDa each) which act as a carrier protein for the A subunit in circulation. Both subunits are produced under separate genetic control. In plasma, FXIII exists as a non-covalent tetrameric complex (320 kDa) of two A-subunits and two B-subunits (A2B2). The concentration of FXIII tetramer in plasma is ~25 μg/mL (~80 nM). An intracellular form of FXIII is found in platelets, megakaryocytes and monocytes. This form of FXIII presents as a dimer of two A-subunits only and has a molecular weight of 160 kDa. The importance of these intracellular stores is demonstrated by the observation that platelets can contribute up to
half of the FXIII activity in platelet rich plasma. The activation of FXIII involves several steps. Thrombin cleaves after Arg37 of each Asubunit in the A2B2 tetramer, releasing a 4.5 kDa activation peptide. Additional conformational changes induced by the binding of calcium, and by dissociation of the B-subunits from the A-subunit dimer are required to obtain full enzyme activity. FXIIIa is a cysteine protease that catalyses the formation of γ-glutamyl-ε-lysyl bonds
between the γ and α chains of polymerised fibrin molecules. Other proteins found crosslinked into fibrin clots by FXIIIa include fibrinogen, α2antiplasmin, fibronectin, vitronectin and von Willebrand factor.

Additional Documentation

Kordia Life Sciences

Facteur XIII & Factor XIII subunit A

Sheep anti-human FXIII subunit A, Aff. Pur. Biotiyilated