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Reference & control plasmas

Order number Description Quantity Delivery time CE
BI 040225 Protein S Normal Control 10x0.5 ml 15-20 days x

Protein S Normal Control

Protein S Normal Control Plasma is used for day-to-day control of Protein S assays.

Protein S is a vitamin K-dependent plasma protein which serves as a cofactor for the anticoagulant activity of activated Protein C in the inactivation of factors V and VIII. Protein S exists in human plasma in two forms, both free and complexed to C4b-binding protein (C4b-BP). Free Protein S may be separated from bound Protein S by a simple precipitation
of the complex with polyethylene glycol (PEG). Only the free form of the molecule is known to express biological activity. Deficiency in Protein S has been associated with thrombosis. In some clinical cases of Protein S deficiency, the deficiency has been one of the free Protein S and not of the total Protein S.


Protein S Normal Control Plasma is a freeze-dried preparation of normal
human plasma for which the Protein S antigen level (total and free) and
clottable Protein S activity has been determined. The antigen level is
assayed by ELISA. The clottable Protein S activity is assayed using Biopool
Bioclot® Protein S Kit (Catalogue #40345).



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