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Reference & control plasmas

Order number Description Quantity Delivery time CE
PB CCAPCR-05 APCR Resistance Donor Plasma 25x0.5 ml 7-10 days x

APCR Resistance Donor Plasma

CRYOcheck APCR Positive Control is recommended for use as a positive control in the clot-based assessment of activated protein C resistance (APCR) in citrated human plasma.

Activated protein C (APC) is a serine protease with potent anticoagulant properties. During normal hemostasis, APC hinders clot formation through a mechanism of proteolytic
inactivation of factors Va and VIIIa. A genetic single point mutation in the APC binding domain of the factor V gene, replacing Arg506 with Gln, was demonstrated to be both inherited and associated with familial thrombophilia. The resulting resistance of factor Va to activated protein C (APCR), often referred to as the factor VLeiden mutation, is now recognized
as a commonly inherited risk factor for venous thrombosis.

Clot-based assays have been described which screen for the presence of APCR using citrated human plasma. It is widely recommended, however, that individuals suspected of expressing this mutation on the basis of clotting assay results, undergo genetic testing. This will confirm the presence of the mutation at the molecular level and further define whether the patient is heterozygous, homozygous or normal.



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