Reference & control plasmas
| Order number |
Description |
Quantity |
Delivery time |
CE |
| TC 5450310 |
TECHNOZYM® vWF:CBA Calibration Set |
5x0.5 ml |
7-10 days |
x |
TECHNOZYM® vWF:CBA Calibration Set
The von Willebrand Factor (vWF) is a large, multifunctional glycoprotein, occupying a key
position in primary haemostasis. It has a multiple structure with several functions:
• It is the carrier protein for Factor VIII in plasma; it forms a complex
and thus protects Factor VIII from early proteolytic decomposition.
• It acts as a mediator for platelet aggregation by attaching itself to platelet membrane
receptors (GP Ib and GP lIb/IIIa) following previous platelet activation.
• It plays a part in primary haemostasis by acting as a mediator between adhesioned platelets
and the subendothelium (lesioned vascular wall).
In order to analyze the adhesive properties, as a rule the platelet aggregation is measured
(measuring system = ristocetin-dependent platelet aggregation).
However, this does not reflect the physiological setting nor the function of the vWF. For
determining the adhesive properties of the vWF, its binding capacity to collagen serves as a
parameter which corresponds to the physiological function of the vWF
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Additional Documentation
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