| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| PB PNP-10 | PNP Platelet Lysate | 25x1 ml | 7-10 days | x |
PNP Platelet LysateCRYOcheck Platelet Lysate is intended for use in the Platelet Neutralization Procedure (PNP) which is useful in detecting the presence of lupus anticoagulants (LA) in citrated human plasma. The activated partial thromboplastin time (APTT) is an established screening assay used to assess the intrinsic coagulation pathway. Abnormal prolongation of the APTT has many etiologies, one of the more common of which is the presence of LA. LA are immunoglobulins which are directed against a variety of anionic phospholipids and/or phospholipid-protein complexes and consequently interfere with in vitro phospholipid dependent coagulation tests. In 1983, Triplett et al. introduced the PNP based on the demonstrated principle that the products of platelet lysis neutralized the inhibitory effect of LA. The PNP offered the further advantage of being able to differentiate between LA and specific factor inhibitors. Subsequently, the SSC Subcommittee on Lupus Anticoagulants established four specific criteria to confirm the presence of LA, including the relative correction of the LA defect by the addition of washed, frozen-thawed platelets, phosphotidylserine or hexagonal phase phospholipids. In a follow-up study the SSC Subcommittee on Lupus Anticoagulants recommended that for samples suspected of having LA, at least one additional screening assay must be performed if the initial assay is negative. |
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