| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| PF 502-01 | Pefakit APC-R Factor V Leiden | 120 tests | 10-15 days | x |
Pefakit APC-R Factor V LeidenPefakit APC-R Factor V Leiden is a plasma based functional assay for the determination of resistance to activated protein C caused by the factor V Leiden mutation (FV:Q506). Activated protein C (APC) resistance is the most frequent hereditary defect associated with deep vein thrombosis. Over 80% of the APC resistance phenotype can be explained by the Factor V Leiden mutation. This defect is caused by point mutation in the factor V gene resulting in a replacement of the amino acid Arg 506 by a Gln residue. The heterozygous (het) defect is associated with a 5 to 10 fold, the homozygous (hom) defect with a 50 to 100 fold increased thrombosis risk. There are two possibilities of detecting factor V (FV) Leiden. Plasma based functional assays identifying the phenotype expression of the defect or genotype determination which can be done by PCR technology. |
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