| Order number | Description | Quantity | Delivery time | CE |
|---|---|---|---|---|
| PB CCC-15 | CryoCheck Clot C | 5x30 tests | 7-10 days | x |
CryoCheck Clot CCRYOcheck Clot C is a clot-based assay intended for the quantitative determination of protein C activity in citrated human plasma. Protein C is a vitamin K-dependent zymogen synthesized in the liver as a single chain polypeptide with a molecular weight of 62,000 Da. In the presence of thrombin, calcium and phospholipids, protein C is converted to an active serine protease which acts as a potent inhibitor of procoagulant factors Va and VIIIa. This inhibition is further enhanced by protein S, a cofactor to protein C.Protein C deficiency has both congenital and acquired etiologies of clinical interest. Acquired deficiencies are found in oral anticoagulant therapy (OAT), liver disease, and disseminated intravascular coagulation (DIC), while congenital deficiencies are commonly associated with an increased risk of venous thrombosis and characterized as follows: Deficiency Protein C Antigen Level Protein C Activity Level Type I diminished diminished Type II normal diminished CRYOcheck Clot C functions by direct activation of protein C in the patient sample using protein C activator. The common pathway of coagulation is initiated with a Russell’s viper venom (RVV-X) reagent to convert factor X to Xa and bypassing all factors above the common pathway. Patients with a protein C deficiency or dysfunction will have shortened CRYOcheck Clot C clotting times relative to patients with normal levels of functional protein C. The clotting time is proportional to the amount of functional protein C in the patient’s plasma and this can be quantified using a calibration curve. |
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