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Specialty kits & reagens

Order number Description Quantity Delivery time CE
TC 5344515 APC Resistance Kit 40 tests 40 tests 10 days x

APC Resistance Kit 40 tests

APC Resistance Kit is a plasma based functional assay for the determination of resistance to activated protein C caused by the factor V Leiden mutation (FV:Q506). Activated protein C (APC) resistance is the most frequent hereditary defect associated with deep vein thrombosis. Over 95% of the APC resistance phenotype can be explained by the Factor V Leiden mutation . This defect is caused by point mutation in the factor V gene resulting in a replacement of the amino acid Arg 506 by a Gln residue]. The heterozygous (het) defect is associated with a 5 to 10 fold, the homozygous (hom) defect with a 50 to 100 fold increased
thrombosis risk. There are two possibilities of detecting factor V (FV) Leiden. Plasma based functional assays identifying the phenotype expression of the defect [1] or genotype determination which can be done by PCR technology].



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