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Specialty kits & reagens

Order number Description Quantity Delivery time CE
PB CCS-15 CryoCheck Clot S 5x30 tests 7-10 days x

CryoCheck Clot S

CryoCheck clot S is a clot-based assay intended for the quantitative determination of protein S activity in citrated human plasma.

Protein S is a vitamin K-dependent glycoprotein with a molecular weight of ~70,000 Da. The mature protein circulates in plasma at a total concentration of 25 μg/mL, 40% free and 60% reversibly bound to c4b-binding protein. The free form of protein S acts as a cofactor to enhance the anticoagulant property of activated protein c, a potent inhibitor of procoagulant factors Va and VIIIa.
Protein S deficiency has both congenital and acquired etiologies of clinical interest. congenital deficiencies are commonly associated with an increased risk of venous thromboembolic disease, while acquired abnormalities are associated with anti-vitamin K therapy, liver disease, disseminated intravascular coagulation (DIc), oral contraceptives, oestrogen therapy, acute phase inflammatory responses, pregnancy, and newborns.
CryoCheck clot S initiates the common pathway of coagulation in plasma using a Russell’s viper venom (RVV-X) reagent to convert factor X to Xa in the presence of activated protein c (APc), bypassing all factors above the common pathway. When mixed with protein S deficient plasma, samples from patients with a protein S deficiency or dysfunction will have shortened CryoCheck clot S clotting times relative to samples with normal levels of functional protein S. The clotting time is proportional to the amount of functional protein S in the patient’s plasma and this can be quantified using a calibration curve.



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