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Specialty kits & reagens

Order number Description Quantity Delivery time CE
CO 4036036 PaIFA Heparin/PF4 Rapid Assay (new name of PIFA) 6 units 1-3 days

PaIFA Heparin/PF4 Rapid Assay (new name of PIFA)

The PaIFA® Heparin/Platelet Factor 4 Rapid Assay is a qualitative in vitro diagnostic device designed for the detection of antibodies to the Platelet Factor 4 (PF4) sensitized microspheres. These antibodies are found in some patients undergoing heparin therapy.

The PaIFA® Heparin/PF4 Rapid Assay is based upon principles of the Particle ImmunoFiltration Assay (PaIFA®). Dyed microparticles coated with purified Platelet Factor-4 (PF-4) protein derived from platelet-rich plasma provide the visual signal for the results of the assay.
The ability of matrixed or non-matrixed particles to move through a filter medium is the measure of the reactivity/non-reactivity of the test sample. The PaIFA® Heparin/PF4 Rapid Assay consists of a MiniReactor device that contains a membrane filtration system, a TEST Result window, CONTROL window, and a push button reagent dispensing system, referred to as the Tower, that contains microparticle-based reaction reagents. The MiniReactor contains a reaction chamber that allows the reagents to react with the sample. The reagent contained in the reagent dispenser is added to the reaction chamber followed by the sample. The reagents contain microparticles coated with purified PF4 protein as well as additional enhancing agents designed to promote rapid aggregation or matrix formation of the particles in the presence of specific antibodies in the test sample. Once the reagents have reacted with the sample in the reaction chamber, the reaction mixture automatically collects over the membrane filtration system. This system acts to filter matrixed particles, while allowing non-matrixed particles to pass through. Thus, a matrixed, reactive sample will be trapped within the membrane. Since the dyed particles are trapped on this filter, no color and hence no particles are able to migrate into the TEST Result window. Conversely, a non-matrixed, non-reactive sample will pass through the membrane filter and into the wicking layers, and color will migrate into the TEST Results window.



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