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Ristocetin cofactor assay

Order number Description Quantity Delivery time CE
CH 299 Ristocetin Cofactor Assay kit 7-10 days x

Ristocetin Cofactor Assay

The Chrono-Log Ristocetin Cofactor Assay is for use in the quantitative determination of Factor VIII Ristocetin Cofactor activity in citrated plasma.

Ristocetin Cofactor Activity in plasma may be determined by the agglutination of a standardized
suspension of platelets in the presence of von Willebrand factor using the antibiotic, Ristocetin.' The Ristocetin Cofactor Activity is the in-vitro activity of the von Willebrand factor, which is responsible for the agglutination of platelets in the presence of Ristocetin. Although the platelets play a passive role in such agglutination there is an absolute requirement that the Ristocetin-dependent receptor be intact. von Willebrand disease is associated with a decrease in von Willebrand factor or Ristocetin Cofactor activity and it is generally accepted that the Ristocetin Cofactor activity is the most useful in vitro assay for the diagnosis of von Willebrand disease. Levels of Ristocetin Cofactor activity are determined by the ability of the test plasma and Ristocetin to induce aggregation in a standardized platelet suspension



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