VerifyNow Aspirin Assay Kit; 25 devices

The VerifyNow Aspirin Assay is a qualitative assay to aid in the detection of platelet dysfunction due to aspirin ingestion in citrated whole blood for the point of care or laboratory setting.

Aspirin affects platelet function by irreversibly inhibiting the cyclooxygenase-1 (COX-1) enzyme involved in the conversion of arachidonic acid to thromboxane A2, which ultimately activates the GP IIb/IIIa receptors involved in platelet aggregation. If aspirin has produced the expected anti-platelet effect, such aggregation will not occur. The VerifyNow Aspirin Assay incorporates the agonist arachidonic acid to activate platelets. The VerifyNow Aspirin Assay is designed to measure platelet function based upon the ability of activated platelets to bind fibrinogen. Fibrinogen-coated microparticles aggregate in whole blood in proportion to the number of unblocked platelet GP IIb/IIIa receptors. Light transmittance increases as activated platelets bind and aggregate fibrinogen-coated beads. The instrument measures this change in
optical signal caused by aggregation.